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Abstract #4515

Semi-Nonlinear Self-Adaptation Normalization Generator (SNSAN) to Improve Generalization of White Matter Hyperintensities Segmentation

Yu Cheng1, Chengyan Wang2, Beini Fei3, Chun-Yi Zac Lo1,4, and He Wang1
1The Institute of Science and Technology for Brain-inspired Intelligence (ISTBI), Fudan University, Shanghai, China, 2Human Phenome Institute, Fudan University, Shanghai, China, 3Zhongshan Hospital Fudan University, Shanghai, China, 4Department of Biomedical Engineering, Chung Yuan Christian University, Taoyuan, Taiwan

Synopsis

Keywords: AI Diffusion Models, White Matter, WMH segmentation, Domain Generalization, Normalization

Motivation: Self-adaptation normalization (SAN) method generalizes lesion segmentation to new sites by using a linear generator to convert inputs to a site-independent style. But it fails when the domain difference is mostly nonlinear.

Goal(s): Develop a semi-nonlinear self-adaptation network(SNSAN) to generalize the White Matter Hyperintensity(WMH) segmentation model to an external site.

Approach: To replace the linear generator, the method blends two SAN results with a pseudo correlation map, later use the gradient reversal method to guide the result to a site-unrelated style.

Results: SNSAN normalizes the input data close to a Gaussian distribution and improves the generalization performance on the data from external site.

Impact: We provide a simple and efficient semi-nonlinear normalization method to enhance the domain generalization, and its performance is better than SAN when the domain gap is affected by more nonlinear factors.

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