Keywords: Preclinical Image Analysis, Preclinical, Prostate Imaging for Recurrence Reporting; Prostate cancer; Recurrence; Interreader agreement.
Motivation: PI-RR assessment is not universally validated and has not yet been extensively studied for diagnostic accuracy and interreader variability.
Goal(s): To evaluate the performance of PI-RR for detecting local recurrence in PCa patients with BCR after radiation therapy (RT) or radical prostatectomy (RP).
Approach: 110 patients who underwent MRI and FDG PET/CT were included. A group of four radiologists with varying experience was recruited for recurrence evaluation.
Results: With a PI-RR of 3 as a cutoff, the AUCs ranged from 0.56 to 0.83 after RT and 0.73 to 0.90 after RP across the four readers. The ICC values were 0.54 and 0.68, respectively.
Impact: PI-RR may serve as a clinical guide to improve the management of recurrent PCa by achieving good diagnostic performance and interreader agreement.
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