Keywords: Quantitative Imaging, Myocardium, T1 Mapping, Repeatability
Motivation: Quantitative myocardial T1 mapping is an invaluable tool for detection and characterization of myocardial fibrosis and infarction. Recent emergence of free-breathing non-ECG-gated techniques requires evaluation of their reliability in controlled experiments.
Goal(s): We evaluated repeatability of free-breathing non-ECG-gated Multitasking and breath-held MOLLI T1 mapping techniques and studied factors influencing them.
Approach: Test-retest study was performed in 15 healthy adult volunteers. Bland-Altman plots and Spearman rank correlation were used for statistical analysis.
Results: Our analysis reveals that while free-breathing technique has low bias, controlling data sampling patterns is needed to prevent high variability of test-retest measurements.
Impact: Reliability of myocardial T1 mapping with free-breathing techniques may benefit from designing controlled data sampling patterns utilizing either external or self-calibrated cardiac/respiratory triggers.
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