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Abstract #4557

Mapping fat-water separated R1, R2*, and fat fraction with bipolar multi-echo MP2RAGE

Jorge Campos Pazmino1, Marc-Antoine Fortin2, Véronique Fortier1,3, Andre van der Kouwe4, Cristian Ciobanu1, Evan McNabb3, Renée-Claude Bider1, and Ives Roger Levesque1,5
1Medical Physics Unit, McGill University, Montreal, QC, Canada, 2Norwegian University of Science and Technology, Trondheim, Norway, 3Medical Imaging, McGill University Health Center, Montreal, QC, Canada, 4Athinoula A. Martinos Center for Biomedical Imaging, Harvard Medical School, Boston, MA, United States, 5Research Institute of the McGill University Helth Centre, Montreal, QC, Canada

Synopsis

Keywords: Quantitative Imaging, Quantitative Imaging, MP2RAGE, Bipolar, R1, R2*, Proton density fat fraction, Multi-echo, Cramér–Rao bounds, Fat-water phantom

Motivation: Multi-Echo Magnetization Prepared Two Rapid Acquisition of Gradient Echoes (ME-MP2RAGE) can be combined with chemical shift-encoded fat-water separation to simultaneously map fat and water-specific R1. However, long echo times in the multi-echo portion of the technique can lead to poor fat-water separation and compromised accuracy and precision of the estimates.

Goal(s): Simultaneous mapping of fat and water-specific R1, R2*, and proton density fat fraction with bipolar ME-MP2RAGE.

Approach: Unipolar and bipolar ME-MP2RAGE sequences were compared in simulation and phantom experiments.

Results: Numerical simulations and phantom experiments showed that bipolar readouts produce more accurate and precise estimates than unipolar alternatives.

Impact: We propose a technique for simultaneous measurement of PDFF, fat and water-specific R1, and R2* combining multi-echo MP2RAGE and fat-water separation. Moreover, we show that bipolar readouts produce more accurate and precise estimates of these parameters using multi-echo MP2RAGE.

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Abstract

Keywords