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Abstract #4569

Identification of cardiac phase in hyperpolarized 13C cardiac MRI using multiphase 1H MRI and unitized 3D patch-based reconstruction

Sung-Han Lin1, Crystal Harrison1, Kelley Derner1, Zohreh Erfani1, and JaeMo Park1,2,3
1Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States, 2Department of Biomedical Engineering, UT Southwestern Medical Center, Dallas, TX, United States, 3Department of Radiology, UT Southwestern Medical Center, Dallas, TX, United States

Synopsis

Keywords: Image Reconstruction, Hyperpolarized MR (Non-Gas), Cardiac phase detection

Motivation: The predetermined trigger delay may fail to acquire 13C images at an unstable heart rate and cause a misalignment between the cardiac phases depicted in structural and metabolic images.

Goal(s): Aim to exploit the volumetric PBSR algorithm to establish an automated alignment workflow to identify the actual cardiac phase for HP 13C images.

Approach: Image pairs of multiple 1H cardiac phases and single-phase 13C images will be reconstructed by 3D PBSR, and the pair with the best similarity/in-focus index will be elected.

Results: The digital phantom and an in-vivo HP 13C cardiac image demonstrated the feasibility of cardiac phase detection.

Impact: The currently proposed automated alignment workflow identifies the actual cardiac phase when the HP 13C images are acquired, and this technique will potentially benefit patients with arrhythmia or pediatric populations.

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Keywords