Keywords: Quantitative Imaging, Metabolism
Motivation: Recently developed constrained quantitative BOLD (c-qBOLD) offers the ability to quantify local cerebral metabolic rate of oxygen (CMRO2). However, it has yet to be applied in a clinical setting.
Goal(s): By imaging patients with carotid occlusions we expect to observe specific disruptions to cerebral blood flow (CBF) and oxygen extraction fraction (OEF) i.e. neurometabolism.
Approach: Patients (N=4) presenting with unilateral carotid occlusions were examined with a 3D constrained qBOLD protocol to map CBF, OEF, and cerebral blood volume, allowing for calculations of local CMRO2.
Results: Data show both global and hemispheric differences in oxygen metabolism compared to healthy subjects.
Impact: The novel c-qBOLD protocol has potential clinical utility as the degree and character of metabolic dysfunction, but can be performed quickly, offers fine spatial resolution (5.8mm3), and avoids uncomfortable calibration procedures.
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