Keywords: MR-Guided Interventions, Fat, lipid composition, early response, neoadjuvant chemotherapy
Motivation: Deregulation of lipid composition, holding a critical role in breast cancer progression, can be accurately mapped using chemical shift-encoded imaging (CSEI), and might support response monitoring in patients undergoing neoadjuvant chemotherapy (NACT).
Goal(s): We aimed to determine the power of CSEI in differentiation of poor responders after one cycle of NACT.
Approach: Seventeen patients were imaged before and after one cycle of NACT to compute the percentage change in monounsaturated, polyunsaturated and saturated fatty acids.
Results: There was a treatment induced lipid normalisation in all participants, however there was no difference in poor responders in comparison to good responders.
Impact: CSEI is sensitive to the longitudinal change in lipid composition in the peri-tumoural region and the whole breast, however the impact on lipid metabolism is secondary to determining poor responder and other markers of metabolic imaging should be explored.
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