(ISMRM 2024) Lipid composition mapping for early response to neoadjuvant chemotherapy in breast cancer using chemical shift-encoded imaging
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Abstract #4608

Lipid composition mapping for early response to neoadjuvant chemotherapy in breast cancer using chemical shift-encoded imaging

Sai Man Cheung1, Kwok-Shing Chan2, Nicholas Senn1, Ravi Sharma3, Trevor McGoldrick3, Tanja Gagliardi1,4, Ehab Husain5, Yazan Masannat6, and Jiabao He1,7
1Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom, 2Massachusetts General Hospital, Boston, MA, United States, 3Oncology Department, Aberdeen Royal Infirmary, Aberdeen, United Kingdom, 4Royal Marsden Hospital, London, United Kingdom, 5Pathology Department, Aberdeen Royal Infirmary, Aberdeen, United Kingdom, 6Breast Unit, Broomfield Hospital, Mid and South Essex NHS Trust, Chelmsford, United Kingdom, 7Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle, United Kingdom

Synopsis

Keywords: MR-Guided Interventions, Fat, lipid composition, early response, neoadjuvant chemotherapy

Motivation: Deregulation of lipid composition, holding a critical role in breast cancer progression, can be accurately mapped using chemical shift-encoded imaging (CSEI), and might support response monitoring in patients undergoing neoadjuvant chemotherapy (NACT).

Goal(s): We aimed to determine the power of CSEI in differentiation of poor responders after one cycle of NACT.

Approach: Seventeen patients were imaged before and after one cycle of NACT to compute the percentage change in monounsaturated, polyunsaturated and saturated fatty acids.

Results: There was a treatment induced lipid normalisation in all participants, however there was no difference in poor responders in comparison to good responders.

Impact: CSEI is sensitive to the longitudinal change in lipid composition in the peri-tumoural region and the whole breast, however the impact on lipid metabolism is secondary to determining poor responder and other markers of metabolic imaging should be explored.

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Keywords

lipidbreastcompositioncycleperiresponderscancerwholepoorgoodpatientstumourpercentagechemotherapyaberdeenfattypolyunsaturatedresponseacidskingdomsaturatedsupporttreatmentmappingchemicalinducedtableencodednormalisationclinical