Keywords: Breast, Cancer, Breast, Response, Chemotherapy
Motivation: To achieve de-escalation of surgery in breast cancer patients having complete response after primary chemotherapy, we require better accuracy than the current gold standard DCE-MRI, which has a sensitivity of 80-90% and a specificity of 37-97%.
Goal(s): Investigate the diagnostic value of biomechanical imaging biomarkers quantified via MR-Elastography (MRE) for gauging complete pathological response non-invasively.
Approach: Incorporate MRE into standard Breast MRI protocol for NACT patients within standard-of-care MRI protocol.
Results: Biomechanical changes in conjunction with DCE MRI improved sensitivity to 94.4% and specificity to 95.7%, making this approach a promising new concept to predict complete response after NACT.
Impact: Quantifying biomechanics throughout chemotherapy via MR-Elastography (MRE) in conjunction with DCE-MRI in breast cancer patients undergoing primary chemotherapy yields more accurate results in predicting complete pathological response than current international imaging gold standard methods.
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