Keywords: Screening, Fat, BRCA1/2, chemical shift-encoded imaging, early detection
Motivation: Deregulation of lipid composition in the breast of BRCA1/2 carriers has been observed using single voxel spectral edited MRS, however the spatial distribution may further distinguish the disease state.
Goal(s): We aimed to determine the power and repeatability of CSEI in detection of lipid deregulation in BRCA1/2.
Approach: Lipid composition maps were acquired from 20 BRCA1/2 and 20 patients, to derive monounsaturated, polyunsaturated and saturated fatty acids in the peri-tumoural region in patients and the whole breast in all subjects.
Results: Lipid composition in BRCA1/2 showed similarity to positive control. CSEI has excellent repeatability in lipid composition mapping of the breast.
Impact: Deregulation of lipid composition in the breast of BRCA1/2 genetic mutation carriers resembles the diseased group, serving as potential precursor of breast cancer. CSEI yields highly repeatable quantitative maps of lipid composition critical for effective disease monitoring.
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