Keywords: Liver, Liver
Motivation: Liver biopsy, traditionally regarded as the benchmark for liver fibrosis staging, is an invasive procedure that may cause infection and bleeding.
Goal(s): To develop a non-invasive method to evaluate liver fibrosis using MRI.
Approach: Diamagnetic sources are separated from paramagnetic sources using a biophysical model and multi echo gradient echo data. The value of the diamagnetic sources can be used to quantify the amount of accumulation of collagen due to liver fibrosis.
Results: Significant differences in liver negative susceptibility were observed between lower stage, medium stage and higher stage of fibrosis.
Impact: Multi-echo gradient echo data may provide a way to non-invasively stage liver fibrosis.
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