Abstract #4630

Improving Self-Gated Radial MR Elastography for Free-Breathing Quantification of Liver Stiffness in Children

Sevgi Gokce Kafali^1,2, Bradley D. Bolster Jr.³, Shu-Fu Shih^1,2, Timoteo I. Delgado^1,4, Vibhas Deshpande⁵, Xiaodong Zhong¹, Timothy R. Adamos⁶, Shahnaz Ghahremani^1,6, Kara L. Calkins⁶, and Holden H. Wu^1,2,4

¹Radiological Sciences, University of California, Los Angeles, Los Angeles, CA, United States, ²Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States, ³US MR R&D Collaborations, Siemens Medical Solutions USA, Inc., Salt Lake City, UT, United States, ⁴Physics and Biology in Medicine Interdepartmental Program, University of California, Los Angeles, Los Angeles, CA, United States, ⁵US MR R&D Collaborations, Siemens Medical Solutions USA, Inc., Austin, TX, United States, ⁶Pediatrics, University of California, Los Angeles, Los Angeles, CA, United States

Synopsis

Keywords: Liver, Pediatric

Motivation: MR elastography (MRE) detects liver fibrosis by measuring hepatic stiffness (HS). Breath-holding (BH) is required to avoid motion artifacts, but this is challenging in children. Previous radial free-breathing (FB) MRE eliminated the BH, but required 2 min/slice.

Goal(s): To reduce scan time for radial FB-MRE and analyze the effects of self-gating on HS.

Approach: Radial FB-MRE was modified to acquire lower resolution and perform spatial interpolation, which reduced the scan time. Self-gating was performed to compensate for breathing motion.

Results: In 23 children, self-gated radial FB-MRE (1 min/slice) yielded more accurate and repeatable HS than non-self-gated radial FB-MRE, with respect to standard BH-MRE.

Impact: Self-gated free-breathing MR elastography (MRE) of the liver produced accurate and repeatable hepatic stiffness in 1 min/slice, with respect to standard cartesian breath-held MRE, and can be beneficial for children who cannot perform breath-holding.

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