Keywords: Kidney, Kidney
Motivation: Non-invasive evaluation of chronic kidney disease (CKD) is of increasing value.
Goal(s): This study aims to assess renal interstitial fibrosis (IF) using diffusion-based MRI approached and their corticomedullary difference (CMD) in CKD patients.
Approach: MRI parameters from apparent diffusion coefficient (ADC), intra-voxel incoherent motion (IVIM), diffusion kurtosis imaging (DKI) and diffusion-relaxation correlated spectrum imaging (DR-CSI) were obtained both for renal cortex and medullary. CMD of these parameters were calculated.
Results: Several diffusion-based MRI parameters are promising for differentiating between the mild and moderate-severe renal IF. CMD shows potential for the assessment of renal IF on a supplementary role.
Impact: This study shows attempts on non-invasive assessment of renal interstitial fibrosis using several typical advanced model or model-free methods regarding diffusion MRI. Also, it illustrates the possible role of renal corticomedullary difference of these approaches in the assessment.
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