Abstract #4634

Evaluation of MRS- and MRI- PDFF and Liver Biopsy measure of hepatic fat fraction in a clinically relevant cohort

Christian Simonsson^1,2,3, Shan Cai^1,2, Jens Tellman¹, Markus Karlsson^1,4, Gunnar Cedersund^2,3, Simone Ignatova⁵, Patrik Nasr⁶, Mattias Ekstedt^2,6, Stergios Kechagias^2,6, Nils Dahlström^2,7, and Peter Lundberg^1,2

¹Department of Radiation Physics, Radiology, Department of Medical and Health Sciences, Linköping University, Linköping, Sweden, ²Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden, ³Department of Biomedical Engineering, Linköping University, Linköping, Sweden, ⁴AMRA Medical AB, Linköping, Sweden, ⁵Department of Clinical Pathology and Clinical Genetics, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden, ⁶Department of Gastroenterology and Hepatology, Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden, ⁷Department of Radiology and Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden

Synopsis

Keywords: Liver, Liver

Motivation: Metabolic Associated Fatty Liver Disease (MAFLD) will increase the burden on future healthcare. Reliable screening alternatives such as MR-techniques e.g., nP-Dixon imaging and proton MR-spectroscopy are widely used. However, the number of studies comparing both MR-techniques with biopsies in clinically relevant cohorts is limited.

Goal(s): Compare MR Dixon imaging and proton MR-spectroscopy fat fraction with histological evaluation of steatosis

Approach: We have compared three different PDFF measurements; MRS, 6- and 2-point Dixon PDFF, in a prospective study, which included 84 clinically relevant patients with diffuse liver disease.

Results: All three techniques could accurately characterize histology based steatosis scores in this clinically relevant cohort.

Impact: In this prospective study, with a clinically relevant cohort, a difference between MRS and Dixon determined PDFF was measured. Both methods could distinguish between different histological levels of steatosis, and both methods could therefore characterize the patient group accurately.

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