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Abstract #4659

AI-Integrated MRS Scan Identifies and Updates Scan Parameters in the Presence of OOV Artifacts

Aaron T. Gudmundson1,2, Kathleen E. Hupfeld1,2, Gizeaddis Simegn1,2, Yulu Song1,2, Helge J. Zöllner1,2, Christopher W. Davies-Jenkins1,2, İpek Özdemir1,2, Michael Schär1,2, Georg Oeltzschner1,2, Sandeep Ganji3, and Richard A. E. Edden1,2
1Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins School of Medicine, Baltimore, MD, United States, 2F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 3Philips Healthcare, Rochester, MN, United States

Synopsis

Keywords: Acquisition Methods, Machine Learning/Artificial Intelligence, Spectroscopy, Brain, Artifacts, Convolutional Neural Network

Motivation: Deep learning is a promising new tool for post-processing MRS data. Neural network-based MRS acquisition methods do not yet exist, but should lead to higher-quality data.

Goal(s): The goal of this work was to create an “intelligent MRS scan” by integrating a Convolutional Neural Network (CNN) directly into a MRS acquisition protocol.

Approach: Here, a CNN-powered pre-scan collects a single-transient from 48 different gradient geometries, and updates future scans, without human intervention, to avoid out-of-voxel (OOV) artifacts.

Results: The AI-informed scan produced high-quality data for all participants while the control parameters failed half of the time in the artifact-rich mPFC region.

Impact: The work demonstrates the first AI-integrated MRS scan protocol in which an intelligent pre-scan modifies scan parameters to improve data quality, here reducing out-of-voxel artifacts.

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Keywords