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Abstract #4684

Using digital reference objects to optimize advance reconstruction methods for abdominal DCE MRI in the presence of motion

Jayant Sakhardande1, Julia Velikina2, Alexey Samsonov2, Eric M Schrauben3, and James Holmes1,4
1Biomedical Engineering, University of Iowa, Iowa City, IA, United States, 2Radiology, University of Wisconsin Madison, Madison, WI, United States, 3Location AMC, Amsterdam UMC, Amsterdam, Netherlands, 4Radiology, University of Iowa, Iowa City, IA, United States

Synopsis

Keywords: Software Tools, Phantoms, digital reference object

Motivation: Concern over gadolinium contrast injections for research purposes limits in vivo testing of new imaging methods. An in-silica optimization strategy is needed when developing advanced reconstructions in the setting of free-breathing abdominal DCE MRI.

Goal(s): Demonstrate a framework for testing performance of different reconstructions.

Approach: A publicly available DRO was used to generate simulated free-breathing abdominal DCE k-space data. Data was then reconstructed using different reconstruction settings for MOCCO and SENSE.

Results: This approach allowed head-to-head comparisons of different reconstruction methods as well as comparison with the ground truth data used to generate the DRO.

Impact: The proposed testing approach allows researchers to test numerous combinations of acquisitions and reconstructions while having ground truth as a benchmark.

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Keywords