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Abstract #4699

Intraoperative Precision Sampling of Tumor Microenvironments based on 7T MRSI: A pipeline development

Sagar Acharya1, Cornelius Cadrien1, Sara Huskic1, Philipp Lazen1, Christina Brenner2, Ahmet Azgin1, Julia Furtner1, Barbara Kiesel1, Lisa Wadiura1, Matthias Preusser1, Thomas Roetzer-Pejrimovsky1, Gunda Köllensperger2, Siegfried Trattnig1, Wolfgang Bogner1, Georg Widhalm1, Karl Rössler1, and Gilbert Hangel1
1Medical University of Vienna, Vienna, Austria, 2University of Vienna, Vienna, Austria

Synopsis

Keywords: Spectroscopy, Contrast Mechanisms, Spectroscopy, Neuro Tumors (Pre-Treatment), Surgery

Motivation: Molecular and pathological diagnosis requires fresh tissues. It is important to achieve precise sampling and preservation of the tumor is for maintaining the tumor integrity.
MRSI can accurately identify tumor hotspots and can be used for obtaining high quality samples.

Goal(s): Develop MRSI pipeline for precise intraoperative tumor sampling.

Approach: We processed 7T MRSI metabolic ratio maps and identified the tumor hotspots. We then correlated them with their quantitatively analyzed metabolic profiles.

Results: We were able to achieve high quality tumor samples based on our 7T MRSI maps.

Impact: Due to high resolution 7T metabolic ratio maps we could identify and define tumor hotspots which resulted in precise tumor sampling. We were also able to preserve the tissue specimens and obtain high quality results.

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Keywords