Abstract #4700

Tissue water referencing for 7T MRSI: Integrating proton density maps into quantitative metabolic mapping

Ahmet Azgın^1,2, Barbara Dymerska³, Martina Callaghan³, Philipp Lazen^1,2, Lukas Hingerl², Bernhard Strasser², Wolfgang Bogner^2,4, Karl Rössler^1,4, Siegfried Trattnig^2,4,5, and Gilbert Hangel^1,2

¹Department of Neurosurgery, Medical University of Vienna, Vienna, Austria, ²High-field MR Center, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Wien, Austria, ³Wellcome Centre for Human Neuroimaging, Department of Imaging Neuroscience, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom, ⁴Christian Doppler Laboratory for MR Imaging Biomarkers, Vienna, Austria, ⁵Institute for Clinical Molecular MRI, Karl Landsteiner Society, St. Poelten, Austria

Synopsis

Keywords: Spectroscopy, Brain, 7T, MRSI, Concentration Estimates

Motivation: In magnetic resonance spectroscopic imaging, generating concentration estimates is desirable. So far, our approach has been limited by the need for WM/GM separation and literature values, limiting it to healthy subjects. To solve this, it can be replaced by PD map-based references.

Goal(s): To test an approach of calculating concentration estimates within volunteers without relying on literature assumptions for reference.

Approach: Use quantitative proton density maps to calculate water concentration maps for metabolic imaging at 7T.

Results: We successfully used ME-GRE imaging to calculate water concentration maps. In healthy volunteers, these maps correspond well to the previous method.

Impact: Using tissue water maps for MRSI concentration estimation allows to not only apply the method to healthy brains, but also to pathologies like gliomas. This will make 7T MRSI a better tool for studies.

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