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Abstract #4701

Data-Driven MRS Signal Decomposition Using Wavelet Analysis

Julian P. Merkofer1, Dennis M. J. van de Sande2, Sina Amirrajab2, Kyung Min Nam3, Ruud J. G. van Sloun1, and Alex A. Bhogal3
1Department of Electrical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands, 2Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands, 3High Field Research Group, Center for Image Sciences, University Medical Center Utrecht, Utrecht, Netherlands

Synopsis

Keywords: Analysis/Processing, Spectroscopy, Wavelet Analysis, Signal Decomposition, Proton MRS

Motivation: Magnetic resonance spectroscopy (MRS) is currently limited by noise, low spatial resolution, and artifacts that compromise the accuracy of metabolite quantification.

Goal(s): This work aims to enhance MRS signal quality without compromising signal integrity, employing wavelet analysis for robust signal decomposition.

Approach: A novel method utilizing wavelet analysis and a U-Net architecture creates masks that segment scalograms, effectively isolating individual metabolites in MRS signals.

Results: The method has shown in simulations the ability to distinctly separate and characterize metabolite signals, offering a promising direction for refining MRS data analysis.

Impact: Provides a data-driven method for MRS signal decomposition based on wavelet analysis that shows success in extracting metabolite and baseline information. It holds the potential for accurate characterization of nuisance signals, which could lead to improved MRS fitting.

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Keywords