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Abstract #4713

Prediction of Lifetime Acute Ischemic Stroke Risk using Multimodal Models and SHAP-based Interpretability Methods

Wenyue Mao1, Yuxiang Dai1, Zhang Shi2, Rencheng Zheng1, Yinghua Chu3, Chengyan Wang4, and He Wang1,4
1Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China, 2Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai, China, 3Simens Healthineers Ltd., Shanghai, China, 4Human Phenome Institute, Fudan University, Shanghai, China

Synopsis

Keywords: Diagnosis/Prediction, Stroke, Stroke occurence prediction; Deep learning

Motivation:
Accurately predicting the lifetime risk of acute ischemic stroke (AIS) remains a significant challenge, and there is a notable scarcity of multimodal models that effectively integrate medical imaging with clinical factors.

Goal(s):
To propose an effective multi-modality deep learning model based on both MR images and clinical factors for improved prediction of AIS occurrence.

Approach:
The model leveraged a clinical-factor-agnostic module to extract clinical features from clinical factors and employed Shapley methods to scrutinize the significance of features.

Results:
The proposed method achieved higher performance than conventional models for the prediction of lifetime AIS occurrence.

Impact: Our model's predictive outcomes could pinpoint individuals at high risk for AIS, allowing clinicians to advise them on self-health vigilance.

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Keywords