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Abstract #4720

Enhanced Solubility and Polarization of 13C-fumarate with Meglumine Allows in vivo Detection of Renal Gluconeogenesis

Mai Huynh1, Zohreh Erfani1, Sarah Al Nemri1, Sara Chirayil1, Zoltan Kovacs1, and Jae Mo Park1,2,3
1Advanced Imaging Research Center, UTSW Medical Center, Dallas, TX, United States, 22. Department of Biomedical Engineering, UTSW Medical Center, Dallas, TX, United States, 3Department of Radiology, UTSW Medical Center, Dallas, TX, United States

Synopsis

Keywords: Probes & Targets, Hyperpolarized MR (Non-Gas), Fumarate, meglumine, hyperpolarization, gluconeogenesis, solubility

Motivation: Clinical translation of many hyperpolarized substrates, including 13C-fumarate, has been obstructed by its low solubility in water, causing rapid precipitation of the substrates after dissolution when prepared in conventional glassing solvents.

Goal(s): The goal of this study was to enhance water solubility and glassing properties of fumarate.

Approach: We introduced a new formulation of fumarate for DNP by using meglumine as a counterion.

Results: Meglumine significantly improved the polarization performance of fumarate with excellent solubility and glassing properties and previously invisible products along gluconeogenesis were observed in rat kidneys in vivo.

Impact: The solubilizing and vitrifying effect of meglumine counterion is not limited to fumarate. It is applicable to other 13C- and 15N-labeled compounds such as carboxylic acids and amino acids that have poor solubility and can form meglumine salts or adducts.

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Keywords