Keywords: Small Animals, Oxygenation
Motivation: T2* MRI and photoacoustic imaging (PAI) offer non-invasive oxygenation measures, but their comparative effectiveness for placental study remains untested.
Goal(s): Our goal was to directly compare T2* MRI and PAI's ability and effectiveness to assess placental and fetal organ oxygenation responses under normoxic hypercapnia challenge.
Approach: Using pregnant rats, the study involved sequential scans of fetoplacental units with T2* MRI and PAI under normoxic hypercapnia challenge.
Results: We found discrepancies between MRI and PAI in detecting oxygenation changes. MRI displayed a marked response in placental oxygenation, not as prominently reflected in PAI measurements.
Impact: T2* MRI could accurately captures fetoplacental responses to hypercapnia, outperforming photoacoustic imaging. Investigating this performance gap is essential before combining these techniques in preeclampsia and fetal growth restriction studies.
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