Abstract #4723

Multi-parametric MRI for Evaluating Variations in Structure, Function, and Metabolites in Acute Kidney Injury Induced by Ischemia Reperfusion

Quan Tao^1,2,3, Qianqian Zhang^2,3,4, Ziqi An^2,3,4, Zelong Chen⁵, Zhigang Wu⁶, Kan Deng⁷, and Yanqiu Feng^1,2,3,4

¹Department of Rehabilitation Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China, ²Guangdong Provincial Key Laboratory of Medical Image Processing, Southern Medical University, Guangzhou, China, ³Guangdong Provincial Engineering Laboratory for Medical Imaging and Diagnostic Technology, Southern Medical University, Guangzhou, China, ⁴School of Biomedical Engineering, Southern Medical University, Guangzhou, China, ⁵Medical Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou, China, ⁶Philips Healthcare, Shenzhen, China, ⁷Philips Healthcare, Guangzhou, China

Synopsis

Keywords: Small Animals, CEST & MT

Motivation: There is lack of a comprehensive MRI technique to comprehensively detect the acute kidney injury (AKI) induced by ischemia reperfusion injury (IRI).

Goal(s): We aimed to develop the mpMRI for diagnosis of AKI induced by ischemia reperfusion IRI.

Approach: The IRI-AKI model of 40-minutes ischemia in rats were established, and mpMRI is conducted at 0, 1, 3, 7, 14, and 28 days. Several MRI indexes signal and their diagnosis performance were compare, respectively.

Results: Multi-parametric MRI may shows comprehensive variations in IRI-AKI, and amine-CEST may exhibits the highest accuracy for diagnosis of IRI-AKI.

Impact: This may provide guideline for clinical application of renal mpMRI.

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