Keywords: Biomarkers, Hyperpolarized MR (Gas), Dynamic Gas Exchange Spectroscopy, Look-locker, Chemical Shift Saturation Recovery, Rapid Acquisition
Motivation: Hyperpolarized 129Xe Chemical Shift Saturation Recovery (CSSR), commonly employed for assessing pulmonary physiological function, is time-consuming and prone to weak signals and potential errors at short exchange times.
Goal(s): To accelerate the acquisition of CSSR while ensuring the precise physiological parameter extraction.
Approach: Techniques of inversion recovery (IR) and look-locker (LL) were combined with conventional CSSR (refer to as IR-LL-CSSR), and the results were compared with that obtained by conventional CSSR and IR-CSSR.
Results: By using the proposed method (IR-LL-CSSR), the acquisition could be accelerated for eight times, and meanwhile preserve the accuracy of the extracted physiological parameters.
Impact: IR-LL-CSSR substantially accelerates CSSR acquisition with 129Xe MRS and also ensures a precise physiological parameter assessment, showing promise for improving the pulmonary assessment in clinic.
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