Keywords: Liver, Elastography
Motivation: MRE-assessed liver stiffness, MRI-derived fat fraction, AST, and FIB-4 are promising predictors for identifying at-risk MASH, which is defined as MASH with fibrosis stage 2 or higher. Some investigators have also proposed an additional criterion, NAS ≥ 4 with at least 1 point in each category.
Goal(s): Assess prediction models for diagnostic accuracy in identifying at-risk MASH under both definitions.
Approach: AUC and its 95% confidence intervals were used to assess the overall diagnostic accuracy.
Results: The additional criterion influenced the performance of prediction models, but liver stiffness remains the most reliable single predictor among non-invasive biomarkers.
Impact: At-risk MASH is defined as a MASH diagnosis with fibrosis stage ≥2. Adding a criterion of NAS≥4 with ≥1 point in each category impacts diagnostic accuracy but liver stiffness remains the most reliable single predictor.
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