Meeting Banner
Abstract #4754

Longitudinal 129Xe MRI Gas-exchange and Exercise Intolerance in Long-COVID

Natally AlArab1, Marrissa J McIntosh1, Andrew D Hahn2, Nicholas D Feeley3, Keegan R Staab4, Jonathan L Percy5, Conner J Wharff1, Jessica C. Sieren1,4, Alejandro Comellas6, Eric A. Hoffman1,4, and Sean B. Fain1,4
1Department of Radiology, University of Iowa, Iowa City, IA, United States, 2Department of Iowa, University of Iowa, Iowa City, IA, United States, 3Institute for Clinical and Translational Sciences, University of Iowa, Iowa City, IA, United States, 4Roy J. Carver Department of Biomedical Engineering, University of Iowa, Iowa City, IA, United States, 5Department of Physics, University of Iowa, Iowa City, IA, United States, 6Department of Internal Medicine, University of Iowa, Iowa City, IA, United States

Synopsis

Keywords: Lung, COVID-19, Hyperpolarized Xenon MRI, Long COVID, Exercise tests

Motivation: Long-COVID symptoms are experienced by 10-20% of COVID-19 patients. 129Xe MRI ventilation and gas-exchange measurements may provide insights into long-COVID-19 patients' recovery.

Goal(s): Use 129Xe MRI to monitor longitudinal recovery (>1 year following infection) of long-COVID patients.

Approach: Thirteen long-COVID participants were evaluated longitudinally using pulmonary function tests, six-minute walk distance (6MWD), quality-of-life, and 129Xe MRI imaging measurements.

Results: Improvements in FEV1 and FVC%pred, dyspnea following exercise, and clinically significant improvements in 6MWD were observed. No significant differences in imaging measurements were observed between visits or between COVID and control groups. Dyspnea and MRI gas-exchange were correlated.

Impact: 129Xe MRI measurements in long-COVID participants suggest persistent gas-exchange abnormalities and exercise intolerance, offering valuable insights for future management and rehabilitation of these patients.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Abstract

Keywords