Keywords: Lung, Hyperpolarized MR (Gas)
Motivation: Several dissolved xenon imaging methods have been proposed to detect impaired gas transfer in the lung. However, none have been validated against a gold standard CSI sequence.
Goal(s): To validate quantitative xenon gas exchange metrics from a 4-echo radial EPSI implementation against those from CSI.
Approach: 4-echo radial EPSI results were compared to CSI in 2 healthy volunteers.
Results: We found good correlations between xenon gas exchange metrics from CSI and radial EPSI and minimal biases (0.4 to 5.8%) between the two methods for the main outcome parameter RBC:M, the ratio of dissolved xenon signals from the blood and in the membrane.
Impact: Our implementation of dissolved xenon imaging using a 4-echo radial EPSI is validated against the reference standard CSI sequence, providing confidence in the quantitative nature of the xenon gas exchange metrics from this method to assess lung diseases.
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