Abstract #4777

Wall Shear Stress Measured with 4D Flow MRI Correlates with Biomarkers of Inflammation and Collagen Synthesis in Aortic Dilation

Filip Hammaréus¹, Chiara Trenti^1,2, Hanna M Björck³, Jan Engvall⁴, Per Eriksson³, Hanna Lekedal^1,5, Anna Lundberg¹, Eva Swahn⁶, Lena Jonasson¹, Lennart Nilsson¹, and Petter Dyverfeldt^1,2

¹Department of Health, Medicine and Caring Sciences (HMV), Linköping University, Linköping, Sweden, ²Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden, ³Department of Medicine, Karolinska Intitute, Solna, Sweden, ⁴Department of Clinical Physiology, and Department of Health, Medicine and Caring Sciences (HMV), Linköping University, Linköping, Sweden, ⁵Östersund hospital, Östersund, Sweden, ⁶Department of Cardiology in Linköping, and Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden

Synopsis

Keywords: Flow, Velocity & Flow, Aortic disease

Motivation: Hemodynamics and circulating biomarkers could offer urgently needed improved risk-stratification in individuals with aortic dilation.

Goal(s): To explore correlations between hemodynamics markers measured with 4D Flow MRI and circulating biomarkers in aortic dilation individuals with tricuspid aortic valves.

Approach: Wall shear stress (WSS) parameters were assessed from 4D flow MRI in cases with dilation and controls. Blood plasma samples were used to quantify the inflammation biomarker IL-6 and several extracellular matrix biomarkers including collagen type I α1 chain (COL1α1).

Results: IL-6 correlated to time-averaged WSS (r=0.54, p<0.001), whereas COL1α1 correlated to the oscillatory shear index (r=0.61, p<0.001).

Impact: The observed correlations between 4D Flow MRI-derived wall shear stress and circulating biomarkers of inflammation and collagen synthesis raises the intriguing possibility that altered aortic hemodynamics causes biomarker leakage from the aortic tissue into the circulation.

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