Abstract #4781

Rotational flow as a marker of left ventricular function between youth and adult T2D subjects

Sungho Park^1,2, Takashi Fujiwara¹, Danny Enge¹, Petter Bjornstad³, Jane Reusch^4,5, and Alex J Barker^1,6

¹Department of Radiology, Children's Hospital Colorado, University of Colorado Anschutz Medical Campus, Aurora, CO, United States, ²Institute of Medical Devices, Kangwon National University, Chuncheon, Korea, Republic of, ³Department of Pediatrics, Division of Endocrinology, University of Colorado School of Medicine, Aurora, CO, United States, ⁴Division of Endocrinology, Metabolism, and Diabetes, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, United States, ⁵Rocky Mountain Regional Veterans Administration Medical Center (VAMC), Aurora, CO, United States, ⁶Department of Bioengineering, University of Colorado Anschutz Medical Campus, Aurora, CO, United States

Synopsis

Keywords: Flow, Cardiovascular, 4D flow MRI, rotational flow, vorticity

Motivation: Rotational flow within the aorta has been associated with cardiovascular disease and ventricular-vascular coupling, but no study has investigated its direct correlation with LV function.

Goal(s): This study aims to explore whether the assessment of rotational flow can effectively identify left ventricle dysfunction between youth and adult type 2 diabetes (T2D) subjects.

Approach: Correlation between global function and strain changes by CMR and rotational flow indices and pulse wave velocity by 4D flow MRI were evaluated.

Results: Adult T2D had significant decrease in vorticity indices with CMR biomarkers, while showing less significance in CMR biomarkers compared to youth T2D.

Impact: Vorticity indices are potential biomarkers to assess LV dysfunction and understand ventricular-vascular coupling even in the absence of geometric anomalies within the aorta. A comprehensive examination of rotational flow and LV function is required.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.