Keywords: Diagnosis/Prediction, Brain, Dementia
Motivation: Normal pressure hydrocephalus (NPH) is a treatable cause of dementia. The treatment with ventriculoperitoneal shunt surgery can lead to sustained improvement in about 80% of cases. However, due to the invasive nature of surgery, improving the predictability of outcomes is imperative.
Goal(s): To assess magnetic resonance elastography (MRE) as a non-invasive tool to predict surgical outcomes in NPH.
Approach: Pre-surgical stiffness and damping ratio pattern scores were used as features to train classification models that predict clinical improvement following shunt placement.
Results: MRE is a promising noninvasive tool for prediction of surgical outcomes in normal pressure hydrocephalus.
Impact: MRE demonstrates promise as a prognostic tool for prediction of surgical outcomes in NPH. If successfully translated to clinic, this would provide patients with non-invasive alternative.
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