Abstract #4791

Determining the Relationship between DTI and MR Elastography Metrics in Highly Anisotropic White Matter Structures at 7T

Em Triolo¹, Oleksandr Khegai², Andrew Frankini², Matthew McGarry³, Priti Balchandani², and Mehmet Kurt^1,4

¹Mechanical Engineering, University of Washington, Seattle, WA, United States, ²Biomedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York City, NY, United States, ³Dartmouth College, Hanover, NH, United States, ⁴Icahn School of Medicine at Mount Sinai, New York City, NY, United States

Synopsis

Keywords: Elastography, Brain

Motivation: Changes in the relationship between MRE and DTI metrics in small white matter structures could indicate alterations in brain microstructure due to white matter damage.

Goal(s): This study aims to determine correlations between metrics measured by MRE and DTI at 7T in the healthy human brain.

Approach: MRE and DTI acquisitions were performed on 14 young, healthy volunteers at 7T, and Shear Stiffness, Damping Raio, FA and RD were calculated for each person.

Results: Significant correlations were found in small, highly anisotropic, brain regions between Shear Stiffness or Damping Raio and FA or RD.

Impact: The high resolutions achieved at 7T for both MRE and DTI allow us to investigate microstructural relationships in small, highly-anisotropic, brain regions. Changes in these metrics or relationships between these metrics could indicate alterations in microstructure integrity, suggesting potential damage.

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