Keywords: Liver, Diffusion/other diffusion imaging techniques, Vessels Encapsulate Tumor Clusters (VETC)，IVIM，HCC
Motivation: To explore a more accurate non-invasive method for predicting VETC pattern in HCC.
Goal(s): To estimate the potential of preoperative IVIM in predicting of VETC pattern in HCC.
Approach: Investigating the correlation between IVIM-derived parameters and the VETC pattern, and constructing a predictive model.
Results: Our results showed that VETC HCC exhibited a declining f value trend and outperformed conventional imaging-clinical models when an integrated model was established, incorporating intratumoral necrosis and high-level AFP. Furthermore, this model is capable of identifying individuals at high risk of postoperative recurrence.
Impact: To our knowledge, this study marks the first time diffusion sequences have been used to predict VETC in HCC, which offers a fresh perspective and paves the way for more accurate VETC direction in the future.
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