Keywords: Diffusion Analysis & Visualization, Multimodal
Motivation: Conventional diffusion-weighted MRI with ADC in clinical breast imaging protocol may not accurately reflect the authentic diffusion.
Goal(s): To quantitatively comparison the diagnostic utility of the compartmentalized diffusion-weighted model-intravoxel incoherent motion (IVIM) and restriction spectrum imaging (RSI) in the differential diagnosis of breast lesions.
Approach: The Mann-Whitney U-test and ROC analysis were used to evaluate the diagnostic efficacy of each parameter and model in differentiating breast lesions.
Results: Quantitative parameters derived from three-compartment RSI model have great promise as imaging indicators in differentiating breast lesions compared to bi-exponential IVIM model. Additionally, the hybrid model integrating IVIM and RSI achieves the superior diagnostic performance.
Impact: The integration of IVIM and RSI would likely lead to a new perspective for the characterization of breast lesions, thus have potential clinical utility in the further application of non-contrast-enhanced breast MR screening.
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