Abstract #4820

DWI Parameters Correlated with Ki-67 Expression, a Prognostic Biomarker, in a Triple-Negative Breast Cancer PDX Mouse Model

Mami Iima^1,2, Marino Akamatsu³, Hirohiko Imai⁴, Hana Suzuki³, Noriko Gotoh⁵, Yasuto Takeuchi⁵, Maya Honda¹, Tomomi Nobashi¹, Masako Kataoka¹, Akihiko Yoshizawa⁶, hiroaki Ito⁷, Tomoe Nakagawa⁸, Minsoo Kim⁹, Denis Le Bihan^10,11, and Yuji Nakamoto¹

¹Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan, ²Institute for Advancement of Clinical and Translational Science (iACT), Kyoto University Hospital, Kyoto, Japan, ³Faculty of Medicine, Kyoto University, Kyoto, Japan, ⁴Department of Systems science, Graduate School of Informatics, Kyoto University, Kyoto, Japan, ⁵Cancer Research Institute, Kanazawa University, Kanazawa, Japan, ⁶Diagnostic Pathology, Nara Medical University, Nara, Japan, ⁷Diagnostic Pathology, Kyoto University Graduate School of Medicine, Kyoto, Japan, ⁸Department of Pathology and Tumor Biology, Kyoto University Graduate School of Medicine, Kyoto, Japan, ⁹Laboratory of Integrative Molecular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan, ¹⁰Human Brain Research Center, Kyoto University Graduate School of Medicine, Kyoto, Japan, ¹¹CEA-Saclay, Paris-Saclay University, NeuroSpin, Gif/Yvette, France

Synopsis

Keywords: Cancer, Breast

Motivation: The lack of reliable biomarkers for assessing tumor characteristics and the limitations of histological analysis due to tumor heterogeneity led to the exploration of diffusion-weighted parameters.

Goal(s): To investigate the association between DW parameters and Ki-67 expression in triple-negative breast cancer, with a focus on whether they can serve as prognostic biomarkers.

Approach: Seventeen triple-negative breast cancer mice with a PDX model underwent 7T MRI scans, yielding DW images. Advanced analysis evaluated ADC and non-Gaussian diffusion parameters, validated through histological Ki-67 staining.

Results: DWI parameters (S-index, sADC, and ADC₀) show strong correlations with Ki67 levels, at short and long diffusion times (9, 27.6ms).

Impact: Promising prognostic biomarkers for triple-negative breast cancer, DWI parameters (S-index, sADC, and ADC₀) displayed strong correlations with Ki-67 expression, at short and long diffusion times. This validation through accurate DWI-pathology comparison highlights imaging's pivotal role in advancing breast cancer diagnosis.

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