Abstract #4838
Enabling reproducible measurements of Fat Fraction and Iron content using an SI traceable reference phantom
Matt Cashmore1, Cailean Clarkson2, Ben P Tatman1, Katie Obee1, Jack Clarke1, Nadia Smith1, Frederic Brochu1, Elizabeth Cooke1, Asha Ford-Scille1, Jessica Goldring1, Robert Hanson1, Asante Ntata1, Susan Rhodes1, Simone Busoni3, Aaron McCann4, Cormac McGrath4, Riccardo Ferrero5, Alessandra Manzin5, Adriano Troia5, Sarah Hill2, Sumiksha Rai6, Stanislav Strepokytov2, Christian Ward-Deitrich6, Alen Bosnjakovic7, Paul Tofts8, Tugba Dispinar9, Ilker Un10, Amy McDowell11, Stephen Wastling11, John Thornton11, Nick Zafeiropoulos11, Sian Curtis12, Richard Scott12, Holly Elbert12, Jonathon Delve12, Cameron Ingham12, Amar Deumić13, Lejla Gurbeta Pokvić13, Merima Smajlhodžić-Deljo13, and Matt Hall1
1National Physical Laboratory, Teddington, United Kingdom, 2National Measurement Laboratory, LGC, Teddington, United Kingdom, 3AOU Careggi, Firenze, Italy, 4Belfast Health and Social Care Trust, Belfast, United Kingdom, 5Istituto Nazionale di Ricerca Metrologica, Torino, Italy, 6National Measurement Laboratory, Teddington, United Kingdom, 7Institute of Metrology of Bosnia and Herzegovina, Sarajevo, Bosnia and Herzegovina, 8Brighton and Sussex Medical School, Brighton, United Kingdom, 9TÜBİTAK, Ankara, Turkey, 10TÜBİTAK, Ankara, United Kingdom, 11University College London, London, United Kingdom, 12University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, United Kingdom, 13VERLAB, Sarajevo, Bosnia and Herzegovina
Synopsis
Keywords: Phantoms, Phantoms, Metrology, Traceability
Motivation: Quantitative MRI is a powerful tool for measuring a variety of biological parameters, with two common biomarkers of interest being fat fraction and Iron content.
Goal(s): We present here a test object for these parameters which is supported by fundamental metrology and traceable to the SI system.
Approach: Initial scan data taken at 1.5T is compared with traceable measurements of phantom properties
Results: We see significant variation seen in clinical results of the same phantom even with standardised protocols, outside the range of phantom validation.
Impact: We demonstrate a new gold standard and verified phantom for fat and iron measurement, traceable to primary standards. We present results using standardised MRI protocols which is vital for understanding and improving standards and best practice guidelines in the future.
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