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Abstract #4844

Predictive Value of Biochemical Recurrence in Advanced Prostate Cancer: Development of Deep Learning-based Radiomics Model

Huihui Wang1, Kexin Wang2, Yaofeng Zhang3, and xiaoying Wang1
1Peking University First Hospital, Beijing, China, 2School of Basic Medical Sciences, Capital Medical University, Beijing, China, 3Beijing Smart Tree Medical Technology Co. Ltd, Beijing, China

Synopsis

Keywords: Diagnosis/Prediction, Radiomics

Motivation: Deep learning forpredicting biochemical recurrence (BCR) is feasible but needs further evaluation in advanced prostate cancer (PCa).

Goal(s): We aimed to develop radiomics models with automatic segmentation derived from pretreatment ADC maps that may be predictive of BCR in advanced PCa.

Approach: In this study, PCa areas were segmented on ADC images by using a pre-trained artificial intelligence (AI) model. Three models were constructed to evaluate BCR prediction level.

Results: The deep-radiomics model was superior than the clinical model and the conventional radiomics model in the aspect of prediction accuracy, clinical impact and risk assessment.

Impact: With accurate BCR prediction by deep-radiomics model, more appropriate treatment plans may be formulated and intervention treatment can be carried out as soon as possible, resulting in better prognosis for patients with PCa.

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