Keywords: Neurofluids, Neurofluids
Motivation: The difference in mLVs outflow between healthy control (HC) and brain disorder patients may contribute to toxic protein aggregation and cognitive decline.
Goal(s): To demonstrate mLVs structure and flow information of brain disorder patients and compare quantitative flow metrics between HC and patient
Approach: We applied IR-ALADDIN to acquire mLVs images around superior sagittal sinus in 20 HCs and 9 patients with various brain disorders such as meningioma, hydrocephalus.
Results: The mLVs size was reduced in patients compared to HC with no significant difference in mLVs velocity, leading to overall mLVs flow reduction in patients.
Impact: The reduced mLVs flow in brain disorder patients was confirmed using a non-invasive technique. This suggests the possibility to study relationship between brain disorders and waste clearance through the mLVs flow in further studies.
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