Abstract #4892

Macromolecular fraction and magnetization exchange rate acquired with UTE-MRI differ in the tibial bone of diabetic rats: a feasibility study

Dina Moazamian¹, Soo Hyun Shin¹, Saeed Jerban², Alireza Tyarani¹, Arya Suprana¹, Hamidreza Shaterian Mohammadi¹, Eddie Fu¹, Christine B Chung^1,3, Yajun Ma², Nigel B Calcutt⁴, Eric Y Chang², and Jiang Du^2,5

¹University of California San Diego, San Diego, CA, United States, ²Radiology, University of California San Diego, San Diego, CA, United States, San Diego, CA, United States, ³Radiology service, VA San Diego Healthcare System, San Diego, CA, United States, ⁴Pathology, University of California San Diego, San Diego, CA, United States, ⁵VA San Diego Healthcare System, San Diego, CA, United States

Synopsis

Keywords: High-Field MRI, Bone, Diabetes bone, UTE-MRI, MMF, Exchange rate

Motivation: Increased risk of fractures in patients with type-2 diabetes mellitus (T2DM) despite higher average bone mineral density is unexplained with routine diagnostic tools like DEXA and CT.

Goal(s): This study aimed to examine the feasibility of using ultrashort echo time (UTE) magnetization transfer (MT) modeling to detect the potential differences between T2DM and normal rats.

Approach: The macromolecular fraction (MMF) and proton exchange rate (k_ab) from UTE-MT modeling on the tibial bone of Zucker diabetic fatty (ZDF) and Zucker lean (ZL) rats were compared.

Results: There was a significant difference in MMF and k_ab measures between the two groups.

Impact: The MMF and kab measures can detect potential bone alternations related to T2DM which may help to better understand the pathogenesis of T2DM bone fractures.

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