Keywords: Small Animals, Brain, TMS, CBV, basal metabolism
Motivation: Transcranial magnetic stimulation (TMS) shows promise as a therapeutic intervention for many neuropsychiatric conditions. Yet, pinpointing the appropriate stimulation target remains elusive.
Goal(s): To identify brain regions affected by prolonged cocaine exposure, and to identify potential targets for focal TMS.
Approach: Basal CBV were mapped by injecting iron-oxide contrast. Multi-echo gradient echo and spin echo sequences were employed to generate maps of 05732972-a323-4027-8676-ccee7744913e">R2.
Results: Many brain regions, including the prelimbic cortex, exhibited a significant decrease in basal CBV following prolonged cocaine exposure. The prelimbic cortex is situated relatively close to the cortical surface and presents a promising candidate for TMS.
Impact: Likely the first attempt to identify TMS targets using the CBV mapping approach.
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