Keywords: Biology, Models, Methods, Multiple Sclerosis, blood brain barrier permeability
Motivation: Blood brain barrier (BBB) dysregulation is one of the earliest signs of multiple sclerosis (MS) and the mechanism underlying BBB breakdown is not completely understood.
Goal(s): We sought to use the non-obese diabetic experimental allergic encephalomyelitis (NOD-EAE) mouse model of secondary progressive MS to understand BBB breakdown in efforts to explore potential MS therapeutics.
Approach: MRI was used to quantify BBB permeability metrics using gadolinium contrast agent.
Results: We quantified the spatial and temporal characterization of BBB permeability in NOD-EAE mice with progressing disease using MRI. These quantifying parameters can potentially be used to test the effect of therapeutic agents on BBB breakdown.
Impact: The NOD-EAE mouse model of secondary progressive multiple sclerosis (SPMS) can potentially be used to assess blood brain barrier characteristics using contrast-enhanced MRI in efforts to test therapeutic agents that can be used in the treatment of SPMS.
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