Keywords: Small Animals, Relaxometry
Motivation: Measuring T2* in mouse brains may therefore be of interest in assessing pathological models or innovative treatments directed against these pathologies.
Goal(s): The goal of this study was to obtain a high resolution and accurate T2* map of the mouse brain ex vivo and in vivo.
Approach: A 3D Multi Gradient Echo sequence with a drift compensation module was used and combined with an optimized fitting model which takes account the non-central chi distribution of the multi-channel gaussian noise.
Results: T2* map were obtained ex vivo and in vivo at 117 µm isotropic resolution in 20 minutes.
Impact: A high-resolution 3D Multi-Gradient Echo sequence sequence has been coupled with an optimized fitting algorithm to generate high resolution T2* map of the mouse brain. This method can be used to study preclinical stroke model.
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