Keywords: Neurofluids, Tumor, CSF circulation, glymphatic system, Diffusion tensor imaging analysis along the perivascular space (ALPS)
Motivation: Limited research has been performed on the role of CSF circulation in the glymphatic transport in patients with glioma.
Goal(s): To evaluate the relationship between CSF circulation disturbance and glymphatic dysfunction in different glioma subtypes.
Approach: A novel measure of glymphatic function (ALPS index) was quantified and compared among 100 patients with different genetic subtypes and associated with CSF circulation related factors and tumor volume.
Results: We found that lower ALPS index in the tumor hemisphere was found in IDH-wildtype glioblastomas and with increasing grade in IDH-mutant gliomas. CSF circulation related factors were correlated with disruptions in glymphatic function.
Impact: Our promising results provide a novel insight of glymphatic dysfunction in patients with glioma.
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