Abstract #4927

Diffusion tensor imaging analysis along the perivascular space in different burdens of cerebral small vessel disease

Na Wang¹, Meng Li², Jing Li³, Xinyue Zhang¹, Changhu Liang¹, and Lingfei Guo¹

¹Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education; Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China, ²Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany; Center for Intervention and Research on adaptive and maladaptive brain Circuits underlying mental health (C-I-R-C), Jena-Magdeburg-Halle, Germany, Jena, Germany, ³Department of Radiology, Beijing Tsinghua Changgung Hospital, Beijing, China

Synopsis

Keywords: DWI/DTI/DKI, Diffusion Tensor Imaging, Diffusion Tensor Imaging along the Perivascular Space

Motivation: Cognitive decline is associated with the impairment of glymphatic clearance, which can be investigated noninvasively using diffusion tensor imaging along the perivascular space (DTI-ALPS).

Goal(s): To investigate the linkage of cerebral small vessel disease (CSVD) burdens with left/right glymphatic function based on DTI-ALPS.

Approach: Glymphatic system function was assessed using diffusion tensor imaging along the perivascular space.

Results: The DTI-ALPS indexes in the CSVD groups were lower than the HC group. Hazard factors for right DTI-ALPS included CSVD severity and sex. Although the right DTI-ALPS index was associated with cognition in univariate analysis, it was not significant in regression analysis.

Impact: The DTI-ALPS technique provides a new opportunity for exploring the damage of CSVD burdens.

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