Keywords: Functional Connectivity, fMRI (resting state), fMRI (task)
Motivation: Understanding hemispheric language dominance is crucial for surgery, yet task-based fMRI has many challenges. Resting-state fMRI shows promise, but its ability to depict language lateralization is still evolving, with varied results in literature.
Goal(s): To assess language dominance on rest fMRI in neurosurgical patients by different methods and seeing concordance with task-based fMRI.
Approach: We explored three calculation techniques for lateralization: first using individual seed volumes, second using voxel activation in ipsilateral hemisphere, and third using net voxel activation generated in bilateral hemispheres
Results: Maximum of 54.55% concordance of rest-fMRI with task-based fMRI was seen for language dominance, with one of the methods.
Impact: Our results emphasize that rest fMRI for language dominance should be used with caution and as an adjunct to task fMRI in neurosurgical patients.
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