Keywords: Blood Vessels, Normal development, high-field MRI
Motivation: Neonatal brain hemorrhage, which are observed in premature and even in full-term infants, could cause adverse neurological damage, however, the mechanism of hemorrhages is unknown and the validated information for neonatal hemorrhages, especially in asymptomatic neonates, is lacking.
Goal(s): Our goal was to detect hemorrhages in the brains of untreated postnatal mice and evaluate the spatiotemporal information.
Approach: T2*-weighted MR images were obtained from records of C57BL/6J mice at P0-1 and acquired hemorrhages were cross-validated by histological analysis.
Results: We found that hemorrhages occur throughout the brain of healthy neonatal mice.
Impact: In vivo MRI of untreated postnatal mice may serve as a useful tool to further investigate asymptomatic hemorrhages in full-term infants and will deepen our understanding of not only the mechanism of neonatal hemorrhages but also the brain development.
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