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Abstract #4983

Characterisation of brain T2* Values across the neonatal period at 7 Telsa

Elisabeth Sarah Pickles1,2, Jucha Willers Moore3,4, Philippa Bridgen1,2, Alena Uus3, Jo V Hajnal2,3, Maria Deprez3, Anthony Price1,3, Tomoki Arichi1,3,4, and Shaihan Malik2,3
1Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom, 2London Collaborative Ultra high field System (LoCUS), London, United Kingdom, 3Centre for the Developing Brain, King's College London, London, United Kingdom, 4Centre for Neurodevelopmental Disorders, King's College London, London, United Kingdom

Synopsis

Keywords: Neonatal, Brain, High-field MRI, Neuro, Relaxometry

Motivation: Brain T2* values can provide information about tissue specific maturation, and can also provide knowledge important for optimising echo times for fMRI acquisition.

Goal(s): To characterise tissue specific T2* values in the neonatal brain at 7T.

Approach: Whole brain T2* maps from 14 neonates were generated using a 3D multi-echo acquisition.

Results: Median T2* values were: cortical grey matter: 58 ms, deep grey matter: 70 ms and white matter: 86 ms. Values differ markedly from those described in adults and measured at standard field strengths.

Impact: We describe tissue-specific T2* values in the neonatal brain at 7T, which may provide new information about brain development in health and disease, and provide a basis for optimising fMRI sequences for neonates at 7T.

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Keywords