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Abstract #4989

Assessing the Effect of Universal Pulses on EDGE-MP2RAGE at 7T

Joelle E. Sarlls1, Gael Saib1, Franck Mauconduit2, Vincent Gras2, and S Lalith Talagala1
1NINDS, National Institutes of Health, Bethesda, MD, United States, 2CEA, NeuroSpin, Universite Paris-Saclay, Gif-sur-Yvette, France

Synopsis

Keywords: Parallel Imaging, High-Field MRI

Motivation: To optimize an EDGE-MP2RAGE acquisition at 7T for epilepsy studies.

Goal(s): To determine if it is beneficial to use Universal Pules within EDGE-MP2RAGE at 7T and to find the optimum TI1 to produce the best visulation of the gray-white matter boundary.

Approach: Collect EDGE-MP2RAGE data with conventional RF and Universal Pulses and analyze the gray and white matter signal across the brain.

Results: Overall, it does seem to be beneficial to use Univeral Pulses within EDGE-MP2RAGE, although it does not produce more consistent gray and white matter signal in all brain regions.

Impact: Utilizing Universal Pulses within EDGE-MP2RAGE with the determined optimum TI1=760ms at 7T can improve continuity of the gray-white matter boundary compared to conventional RF pulses, which may allow for detection of focal cortical dysplasia in epilepsy patients.

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Keywords