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Abstract #5044

MRI metrics can help explain the loss of functional strength in aging

Mary Elizabeth Hall1, Yael Vainberg1, Jessica Asay1, Jennifer Hicks2, Julie Muccini1, Garry Gold1, and Valentina Mazzoli3
1Radiology, Stanford University, Stanford, CA, United States, 2Bioengineering, Stanford University, Stanford, CA, United States, 3Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University, New York, NY, United States

Synopsis

Keywords: Muscle, Aging

Motivation: There is a need to investigate the relationship between age-related muscle atrophy and functional strength.

Goal(s): To explore the relationship between volumes of individual knee extensor muscles relative to total volume of the quadriceps as measured by MRI and sit to stand performance.

Approach: Participants performed a sit to stand test while being recorded by a markerless motion capture system and underwent an MRI exam that included a Dixon scan, which was used to calculate muscle volumes in the quadriceps.

Results: There were correlations between age and vastus intermedius and vastus lateralis volume. Rectus femoris volume was correlated with sit to stand performance.

Impact: We utilized a novel experimental design using smartphone-based markerless motion capture and MRI metrics to study the relationship between functional strength and age-related muscle atrophy. This work could inform design of physical therapy programs for the elderly.

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