Keywords: Diffusion Modeling, Diffusion/other diffusion imaging techniques, cancer
Motivation: The heterogeneity of T2 in tumors and its influences on estimates of tissue microstructure using diffusion MRI are poorly understood.
Goal(s): Assessing how T2 heterogeneity biases IMPULSED-derived metrics of tumor microstructure and evaluating the potential of estimating multi-compartmental T2 and microstructural parameters simultaneously.
Approach: This study quantifies the impact of T2 relaxation on IMPULSED-derived microstructural parameters using simulations and in vivo animal MRI in five tumor models, including brain, breast, prostate, melanoma, and colon cancer.
Results: TE has a negligible impact on IMPULSED-derived cell sizes, and the TE-dependence of IMPULSED-derived intracellular volume fractions can be used to estimate the compartmental T2 values.
Impact: Findings in this study contribute to the ongoing development and refinement of practical, non-invasive MRI techniques for characterizing tissue microstructure.
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