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Abstract #5098

Spherical tensor diffusion encoding with spectral specificity and isotropy

Eric S. Michael1, Runpu Hao1, Franciszek Hennel1, and Klaas P. Pruessmann1
1Institute for Biomedical Engineering, ETH Zurich and University of Zurich, Zurich, Switzerland

Synopsis

Keywords: Diffusion Acquisition, New Signal Preparation Schemes, Spherical b-tensor encoding, oscillating gradient diffusion encoding

Motivation: Lack of spectral selectivity in spherical tensor diffusion encoding impairs the specificity of the measurement.

Goal(s): The goal of this work was to design diffusion gradient waveforms yielding a spherical b-tensor with frequency-specific and isotropic spectral projections.

Approach: Gradient waveform designs derived from oscillating gradient diffusion methodology were conceived by shifting and overlapping cosine-modulated trapezoidal oscillations along the three coordinate axes to achieve orthonormality of the b-tensor.

Results: The proposed gradient waveforms achieved frequency-specific and isotropic diffusion encoding, permitting frequency-dependent diffusion measurements in the in vivo human brain in the same manner as is conventionally performed using multidirectional linear tensor diffusion encoding.

Impact: The proposed diffusion gradient waveforms for spectrally specific and isotropic spherical tensor encoding offer selective frequency measurements that can isolate the signatures of time-dependent diffusion, thereby enabling the study of diffusion dispersion in the framework of tensor-valued encoding.

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